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M. Sc. Heiner Veith

M. Sc. Heiner Veith Foto von M. Sc. Heiner Veith

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Fakultät Bio- und Chemieingenieurwesen
Emil-Figge-Str. 70
44227 Dortmund

Raum G2-109a

Solvate and Hydrate Formation of Pharamaceuticals

Abstract:

Many Active Pharmaceutical Ingredients (API) might be present in different solid states (different polymorphs, hydrates, solvates, salts, or cocrystals) [1]. All those solid forms result in completely different physico-chemical properties and therefore need to be characterized in detail during the development of a pharmaceutical formulation. Commonly, the different solid forms of an API are determined via time-consuming and expensive screening approaches.

 

Description:

The aim of this work is to investigate the solvate formation of APIs. Solvate formation and stability will be experimentally investigated and thermodynamically modelled with the equation of state Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) [2] in order to gain a fundamental understanding of the solvate formation of new APIs.

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References:

[1] W. Jones, W. S. Motherwell and A. V. Trask:
"Pharmaceutical Cocrystals"
MRS Bulletin, vol. 31(11), pp. 875-879, 2006
[2] J. Gross and G. Sadowski:
"Perturbed-Chain SAFT: An equation of state based on a perturbation theory for chain molecules"
Industrial & Engineering Chemistry Research, vol. 40(4), pp. 1244-1260, 2001