Fakultät Bio- und Chemieingenieurwesen Emil-Figge-Str. 70 44227 Dortmund
Abstract:
Many Active Pharmaceutical Ingredients (API) might be present in different solid states (different polymorphs, hydrates, solvates, salts, or cocrystals) [1]. All those solid forms result in completely different physico-chemical properties and therefore need to be characterized in detail during the development of a pharmaceutical formulation. Commonly, the different solid forms of an API are determined via time-consuming and expensive screening approaches.
Description:
The aim of this work is to investigate the solvate formation of APIs. Solvate formation and stability will be experimentally investigated and thermodynamically modelled with the equation of state Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) [2] in order to gain a fundamental understanding of the solvate formation of new APIs.
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