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Fakultät Bio- und Chemieingenieurwesen

M.Sc. Ineke Fahrig

Influence of Surfactants on the Loss of Congruency in ASDs

11/01/2022 - 10/31/2025

Combining active pharmaceutical ingredients (API) and Polymers in amorphous solid dispersions (ASD) enhances aqueous solubility and release of new APIs. However, ASDs with higher drug load may release the API and Polymer incongruently related to amorphous-amorphous phase separation during dissolution. Ternary ASDs containing surfactants increase the drug load at which congruent release is achieved, the so-called ‘Limit of congruency’ (LoC).