The group focuses on thermodynamics of biomolecule solutions. The biomolecules of interest are low-molecular weight components like sugar (and sugar derivates), amino acids and peptides, osmolytes, and electrolytes or ionic liquids. Besides, also larger molecules (polycarbonates and proteins) are considered. The physico-chemical properties, phase behaviors, and reaction equilibria are investigated in detail. Experimental data is measured where not available in literature. These data are modeled via equations of state in order to simultaneously describe phase and reaction equilibria. Moreover, modeling allows for predicting the influence of additives (e.g. salts, buffer, pH, cofactors, enzymes) on the phase and reaction equilibria.
Abstract:
Aim of this work is to thermodynamically describe single reaction steps of the glycolysis metabolic pathway for which current works fail to explain its occurrence.
Abstract:
Aim of this work is to predict solubility of amino acids and peptides in water and in water+organic solvent mixtures and the validation with experimental data
Abstract:
In this project the influence of high pressure and solutes on thermodynamic properties of biological systems is investigated. Furthermore, pressure and solute influence on kinetics of chemical and biochemical reactions are investigated.
Abstract:
This work is focused on the prediction of co-solvents and co-solute effects on the reaction equilibria and Michaelis constants of enzyme-catalyzed reactions.
