Prof. Dr. Gabriele Sadowski
Small molecule pharmaceutics and complex liquid systems
Projects
Influence of coating materials on ASD stability
Many active pharmaceutical ingredients (APIs) suffer from low aqueous solubility, limiting their bioavailability. Bioavailability can be improved by dissolving the API in a polymer, yielding so-called amorphous solid dispersions (ASDs). This project aims at investigating the influence of coating materials, temperature and relative humidity (RH) on the stability of coated ASDs during storage.
Using Polymer Salts as Excipients in Amorphous Solid Dispersions
The bioavailability of active pharmaceutical ingredients (API) is often limited by their low aqueous solubility. The API bioavailability can be improved by dissolving the API in a polymer matrix leading to so-called amorphous solid dispersions (ASDs). This project investigates ASDs using polymer salts as matrix formers. It is performed in close cooperation with the group of Lynne Taylor from Purdue University.




