Dr.-Ing. Dominik Borrmann
Projects
Controlling Quality and Kinetics of Drying Processes for ASDs
Amorphous solid dispersions (ASDs) are popular pharmaceutical formulation to improve the bioavailability of poorly water-soluble drug candidates. ASDs are produced via solvent-based processes with subsequent drying. This project focuses on the equilibrium and drying kinetics of pharmaceutical-relevant polymers and ASDs by coupling thermodynamic and diffusion modeling.
Influence of coating materials on ASD stability
Many active pharmaceutical ingredients (APIs) suffer from low aqueous solubility, limiting their bioavailability. Bioavailability can be improved by dissolving the API in a polymer, yielding so-called amorphous solid dispersions (ASDs). This project aims at investigating the influence of coating materials, temperature and relative humidity (RH) on the stability of coated ASDs during storage.